Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

@article{Romer2004SuppressionOT,
  title={Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.},
  author={Justyna T Romer and Hiromichi Kimura and Susan Magdaleno and Ken Sasai and Christine Fuller and Helen Baines and Michele Connelly and Clinton F Stewart and Stephen Gould and Lee L Rubin and Tom Curran},
  journal={Cancer cell},
  year={2004},
  volume={6 3},
  pages={229-40}
}
Medulloblastoma is the most common malignant pediatric brain tumor. Current treatment is associated with major long-term side effects; therefore, new nontoxic therapies, targeting specific molecular defects in this cancer, need to be developed. We use a mouse model of medulloblastoma to show that inhibition of the Sonic Hedgehog (Shh) pathway provides a novel therapy for medulloblastoma. A small molecule inhibitor of the Shh pathway, HhAntag, blocked the function of Smoothened in mice with… CONTINUE READING
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