Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4.

@article{Yang2008SuppressionOT,
  title={Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4.},
  author={Ying-Hua Yang and Yu Wang and Karen Siu-Ling. Lam and Ming-hon Yau and Kenneth K. Y. Cheng and Jialiang Zhang and Weidong Zhu and Donghai Wu and Aimin Xu},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2008},
  volume={28 5},
  pages={835-40}
}
OBJECTIVE Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein that has recently been implicated in the regulation of angiogenesis and metastasis. This study aimed to investigate the structural and cellular basis underlying the biological actions of Angptl4. METHODS AND RESULTS Circulating Angptl4 was proteolytically cleaved into NH2-terminal coiled-coil domain (N-Angptl4) and COOH-terminal fibrinogen-like domain (C-Angptl4). Using amino acid sequencing analysis, we identified a… CONTINUE READING

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