Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor

@article{Okamoto1992SuppressionOT,
  title={Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor},
  author={Hitoshi Okamoto and Y. Iwahisa and Mitsuo Terasawa},
  journal={Agents and Actions},
  year={1992},
  volume={35},
  pages={149-158}
}
A novel and potent antagonist of platelet-activating factor (PAF), Y-24180 (4-(2-chlorophenyl)-2-[2-(4-isobubylphenyl)ethyl]-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4] diazepine) was investigated for the effects on the skin reactions induced by chemical mediators and the Arthus reactions. In the rat dorsal skin, Y-24180 (0.1–10 mg/kg, p.o… CONTINUE READING