Suppression of sweet sensitivity by potassium gymnemate.

@article{Warren1959SuppressionOS,
  title={Suppression of sweet sensitivity by potassium gymnemate.},
  author={R M Warren and Carl Pfaffmann},
  journal={Journal of applied physiology},
  year={1959},
  volume={14 1},
  pages={
          40-2
        }
}
The leaves of Gymnema sylvestre, when chewed, temporarily depress sensitivity to sweet and bitter substances. The active principle, potassium gymnemate, was isolated and shown to have quantitatively equal effects on the sweet taste of threshold and suprathreshold concentrations of sucrose and sodium saccharin. The possible mechanisms of action are discussed. Submitted on December 10, 1956 
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98 Citations
Background Citations
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Methods Citations
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98 Citations

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Inhibition of the Sweet Taste by Gymnema sylvestre
TLDR
Gymnema sylvestre, a plant used in the Ayurevedic medicine of India for the treatment of diabetes mellitus, selectively and temporarily reduces sensitivity to sweet substances.
Human judgments of Gymnema sylvestre and sucrose mixtures.
Gymnemic acids: Secondary plant substances of dual defensive action?
Effects of Gymnema sylvestre on complex tastes elicited by amino acids and sucrose.
Potassium gymnemate and the sweet and bitter taste provoked electrically
TLDR
Electrical taste stimulation apparently bypasses the most peripheral process by which taste solutions elicit sweet and bitter and thus acts directly on the receptor and/or its afferent nerve terminals.
Structure studies of new antisweet constituents from Gymnema sylvestre
Failure of Gymnema extract to inhibit the sugar receptors of two invertebrates.
Constuents from Gymnema sylvestre leaves. V. Isolation and preliminary characterization of the gymnemic acids.
The objectives of this investigation were to isolate and characterize the constituents of gymnemic acid, the antisweet principle of Gymnema sylvestre leaves, and to make them available for further…
Mechanism of the Action of Taste-modifying Protein
TLDR
A psychological study of the protein designed to clarify its mechanism of action is described, which modifies taste so that sour substances taste sweet.
Consuming Gymnema sylvestre Reduces the Desire for High-Sugar Sweet Foods
TLDR
Consuming gymnema-containing mints compared to placebo significantly reduced the quantity of chocolate eaten mainly due to a decrease in the desire and pleasantness of consuming it.
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