Suppression of splenic lymphocyte function by 7,12-dimethylbenz[a]anthracene (DMBA) in vitro.

@article{Thurmond1988SuppressionOS,
  title={Suppression of splenic lymphocyte function by 7,12-dimethylbenz[a]anthracene (DMBA) in vitro.},
  author={Linda M. Thurmond and Robert V. House and Lloyd D. Lauer and Jack H. Dean},
  journal={Toxicology and applied pharmacology},
  year={1988},
  volume={93 3},
  pages={369-77}
}
The effects of the immunosuppressive polycyclic aromatic hydrocarbon (PAH) 7,12-dimethylbenz[a]anthracene (DMBA) were studied directly by in vitro exposure of splenic lymphocytes. On the basis of evidence from prior studies that DMBA immunotoxicity in vivo may not be dependent upon induction of the Ah locus in mice, splenocytes from Ah-responsive B6C3F1, Ah… CONTINUE READING