Suppression of sleep-induced growth hormone secretion by anticholinergic agent abolishes dawn phenomenon.

@article{Davidson1988SuppressionOS,
  title={Suppression of sleep-induced growth hormone secretion by anticholinergic agent abolishes dawn phenomenon.},
  author={Mayer B. Davidson and Melissa D. Harris and Frederick H Ziel and Craig Rosenberg},
  journal={Diabetes},
  year={1988},
  volume={37 2},
  pages={166-71}
}
The dawn phenomenon was evaluated in eight C-peptide-negative type I (insulin-dependent) diabetic patients on two occasions by measuring glucose concentrations every 30 min from 2400 to 0800 h while the subjects were receiving an insulin infusion (0.12 mU.kg-1.min-1). In random order at 2230 h, they orally received either a sleeping medication alone or with 5.0 mg methscopolamine bromide, an anticholinergic agent. The peak growth hormone (GH) concentrations (ng/ml +/- SE) after sleep were… CONTINUE READING