Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

@article{Shibasaki1997SuppressionOS,
  title={Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2},
  author={Futoshi Shibasaki and Eisaku Kondo and Tadaatsu Akagi and Frank McKeon},
  journal={Nature},
  year={1997},
  volume={386},
  pages={728-731}
}
It is not known how the protein Bcl-2 inhibits cell death induced by calcium signalling and growth-factor withdrawal1–3. Here we report that Bcl-2 forms a tight complex with calcineurin, resulting in the targeting of calcineurin to Bcl-2 sites on cytoplasmic membranes, and show that this interaction is dependent on the BH4 domain of Bcl-2. Calcineurin bound to Bcl-2 is an active phosphatase but is unable to promote the nuclear translocation of NF-AT, a transcription-factor required for… 
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