Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

  title={Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2},
  author={F. Shibasaki and E. Kondo and T. Akagi and F. McKeon},
  • F. Shibasaki, E. Kondo, +1 author F. McKeon
  • Published 1997
  • Biology, Medicine
  • Nature
  • It is not known how the protein Bcl-2 inhibits cell death induced by calcium signalling and growth-factor withdrawal1–3. Here we report that Bcl-2 forms a tight complex with calcineurin, resulting in the targeting of calcineurin to Bcl-2 sites on cytoplasmic membranes, and show that this interaction is dependent on the BH4 domain of Bcl-2. Calcineurin bound to Bcl-2 is an active phosphatase but is unable to promote the nuclear translocation of NF-AT, a transcription-factor required for… CONTINUE READING
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