Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

@article{Shibasaki1997SuppressionOS,
  title={Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2},
  author={F. Shibasaki and E. Kondo and T. Akagi and F. McKeon},
  journal={Nature},
  year={1997},
  volume={386},
  pages={728-731}
}
  • F. Shibasaki, E. Kondo, +1 author F. McKeon
  • Published 1997
  • Biology, Medicine
  • Nature
  • It is not known how the protein Bcl-2 inhibits cell death induced by calcium signalling and growth-factor withdrawal1–3. Here we report that Bcl-2 forms a tight complex with calcineurin, resulting in the targeting of calcineurin to Bcl-2 sites on cytoplasmic membranes, and show that this interaction is dependent on the BH4 domain of Bcl-2. Calcineurin bound to Bcl-2 is an active phosphatase but is unable to promote the nuclear translocation of NF-AT, a transcription-factor required for… CONTINUE READING
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    References

    SHOWING 1-10 OF 23 REFERENCES
    Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.
    • 355
    • PDF
    Calcineurin functions in Ca(2+)-activated cell death in mammalian cells
    • 255
    • PDF
    Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.
    • T. Sato, M. Hanada, +7 authors H. Wang
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1994
    • 580
    • PDF
    Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.
    • 856
    • PDF