Suppression of reward-induced dopamine release in the nucleus accumbens in animal models of depression: Differential responses to drug treatment.

@article{Minami2017SuppressionOR,
  title={Suppression of reward-induced dopamine release in the nucleus accumbens in animal models of depression: Differential responses to drug treatment.},
  author={Saki Minami and Hiroshi Satoyoshi and Soichiro Ide and Takeshi Inoue and Mitsuhiro Yoshioka and Masabumi Minami},
  journal={Neuroscience letters},
  year={2017},
  volume={650},
  pages={
          72-76
        }
}
Anhedonia, the loss of interest or pleasure in previously enjoyable activities, is a core symptom of major depressive disorder, suggesting that the brain reward system may be dysfunctional in this condition. Neurochemical changes in the mesolimbic dopamine (DA) system are not fully understood in animal models of depression. We investigated reward (30% sucrose intake)-induced DA release in the nucleus accumbens (NAc) and the effect of chronic treatment with the antidepressant escitalopram (5mg… CONTINUE READING
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