Suppression of retinoic acid receptors may contribute to embryonic skeleton hypoplasia in maternal rats with chronic vitamin A deficiency.

@article{Li2010SuppressionOR,
  title={Suppression of retinoic acid receptors may contribute to embryonic skeleton hypoplasia in maternal rats with chronic vitamin A deficiency.},
  author={Na Li and Shanshan Sun and Di Wang and Ping Yao and Xuefeng Yang and Hong Yan and Yukai Du and Chengjiang Ying and Liegang Liu},
  journal={The Journal of nutritional biochemistry},
  year={2010},
  volume={21 8},
  pages={710-6}
}
Vitamin A (VA) is essential for embryonic development and the retinoic acid receptors (RARs) are crucial in mediating the diverse actions of VA in embryogenesis. However, the association between RARs and teratogenicity on skeleton growth and development of vitamin A deficiency (VAD) is not clear. In this present study, weaning female Sprague-Dawley rats were fed purified diets containing graded levels of VA (0, 0.4, 4 IU/g diet) for 70 days before mating, and some of them were supplemented with… CONTINUE READING