Suppression of retinal neovascularization by shRNA targeting HIF-1alpha.

  title={Suppression of retinal neovascularization by shRNA targeting HIF-1alpha.},
  author={Xiaobo Xia and Si-qi Xiong and Hui-zhuo Xu and Jian Jiang and Yan Li},
  journal={Current eye research},
  volume={33 10},
PURPOSE To investigate whether vector-based HIF-1alpha -targeted shRNA expression system (pSUPER(siHIF-1alpha)) can inhibit HIF-1alpha and VEGF expression in vitro and suppress retinal neovascularization in the murine model of oxygen-induced retinopathy. METHODS pSUPER(siHIF-1alpha) from which siRNA targeting HIF-1alpha could be generated was constructed and transfected to human umbilical vein endothelial cell lines (HUVECs). Then the expression levels of HIF-1alpha and VEGF in the cultured… CONTINUE READING
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