Suppression of renin-angiotensin system in the heart of spontaneously hypertensive rats.

@article{Rosenthal1987SuppressionOR,
  title={Suppression of renin-angiotensin system in the heart of spontaneously hypertensive rats.},
  author={Julian H Rosenthal and Nicola von Lutterotti and M Thurnreiter and Sz. Gomba and J Rothemund and Werner Reiter and Stanislav Kazda and Bernward Garthoff and Ivonne Jacob and Herbert Dahlheim},
  journal={Journal of hypertension. Supplement : official journal of the International Society of Hypertension},
  year={1987},
  volume={5 2},
  pages={S23-31}
}
Renin-like enzyme and angiotensin converting enzyme (ACE) were identified and their specific activities measured in cardiac tissues of spontaneously hypertensive rats (SHR) and their Wistar-Kyoto (WKY) normotensive controls. In addition, the enzyme activities were determined following administration of hypotensive drugs. The pH optima of cardiac renin-like enzymes were identical with those in vascular walls, the specific activity being higher in the heart. Cardiac ACE revealed similarities with… CONTINUE READING