Suppression of renal tubulointerstitial fibrosis by small interfering RNA targeting heat shock protein 47.

Abstract

BACKGROUND/AIM Unilateral ureteral obstruction (UUO) is a well-established model for tubulointerstitial fibrosis. During the progression of tubulointerstitial fibrosis, upregulation of collagen synthesis and subsequent accumulation of collagen were observed in the tubulointerstitial area. Heat shock protein 47 (HSP47) is a collagen-specific molecular… (More)

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