Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. II. Gene array analysis reveals adaptive changes in cell cycle and cell death pathways.

Abstract

Sertoli cells are essential for testicular germ cell maintenance and survival. We made the unexpected observation that x-radiation (x-ray)-induced germ cell loss is attenuated by co-exposure with the Sertoli cell toxicant 2,5-hexanedione (HD). The mechanisms underlying this attenuation of germ cell apoptosis with reduced Sertoli cell support are unknown… (More)
DOI: 10.1093/toxsci/kfq204

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@article{Campion2010SuppressionOR, title={Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. II. Gene array analysis reveals adaptive changes in cell cycle and cell death pathways.}, author={Sarah N Campion and E. Andres Houseman and Moses A. Sandrof and Janan B Hensley and Yunxia Sui and Kevin W Gaido and Zhijin Wu and Kim Boekelheide}, journal={Toxicological sciences : an official journal of the Society of Toxicology}, year={2010}, volume={117 2}, pages={457-65} }