Suppression of radiation-induced neoplastic transformation of human cell hybrids by long term incubation at low extracellular pH.

@article{Mendonca1990SuppressionOR,
  title={Suppression of radiation-induced neoplastic transformation of human cell hybrids by long term incubation at low extracellular pH.},
  author={Marc S. Mendonca and Chen Sun and J. Leslie Redpath},
  journal={Cancer research},
  year={1990},
  volume={50 7},
  pages={2123-7}
}
We have previously reported that, when 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid buffer was used in the growth medium to control pH fluctuations during the 21-day expression period of our human cell hybrid (HeLa x skin fibroblast) transformation assay, the yield of radiation-induced neoplastically transformed foci after 7 Gy of gamma-irradiation was suppressed. We now demonstrate that the observed suppression is not related to the presence of the 4-(2-hydroxyethyl)-1… CONTINUE READING