Suppression of prostate cancer cell rolling and adhesion to endothelium by 1α,25-dihydroxyvitamin D3.

@article{Hsu2011SuppressionOP,
  title={Suppression of prostate cancer cell rolling and adhesion to endothelium by 1α,25-dihydroxyvitamin D3.},
  author={Jong-Wei Hsu and Sayeda Yasmin-Karim and Michael R. King and Joel C Wojciechowski and Deanne M. Mickelsen and Martha L Blair and H M Ting and Wen-Lung Ma and Y Lee},
  journal={The American journal of pathology},
  year={2011},
  volume={178 2},
  pages={872-80}
}
Adhesion of circulating prostate cancer (PCa) cells to the microvascular endothelium is a critical step during cancer metastasis. To study PCa cell rolling and adhesion behavior, we developed a dynamic flow-based microtube system to mimic the microvascular environment. We found that PCa cell rolling capacity is mediated by E-selectin and can be enhanced by… CONTINUE READING