Suppression of properties associated with malignancy in murine melanoma-melanocyte hybrid cells.

@article{Wakeling1992SuppressionOP,
  title={Suppression of properties associated with malignancy in murine melanoma-melanocyte hybrid cells.},
  author={W. F. Wakeling and J. Greetham and Liam M. Devlin and Dorothy C Bennett},
  journal={British Journal of Cancer},
  year={1992},
  volume={65},
  pages={529 - 537}
}
Murine and human melanoma cells differ relatively reliably from non-tumorigenic melanocytes in certain biological properties. When cultured at low pH, melanocytes tend to be pigmented and melanoma cells unpigmented. The growth of virtually all metastatic melanoma cells is inhibited by phorbol esters such as TPA (12-O-tetradecanoyl phorbol-13-acetate), which stimulate melanocyte growth. Melanocytes fail to grow in suspension culture or produce tumours when implanted in animals, while many… CONTINUE READING