Suppression of proliferative responses of lymphocytes to food antigens by an anti-allergic drug, ketotifen fumarate, in patients with food-sensitive atopic dermatitis.

@article{Kondo1994SuppressionOP,
  title={Suppression of proliferative responses of lymphocytes to food antigens by an anti-allergic drug, ketotifen fumarate, in patients with food-sensitive atopic dermatitis.},
  author={N. Kondo and O. Fukutomi and T. Kameyama and T. Nishida and G. Li and H. Agata and M. Shinbara and S. Shinoda and M. Yano and T. Orii},
  journal={International archives of allergy and immunology},
  year={1994},
  volume={103 3},
  pages={
          234-8
        }
}
  • N. Kondo, O. Fukutomi, +7 authors T. Orii
  • Published 1994
  • Medicine
  • International archives of allergy and immunology
  • Experimental studies have shown that ketotifen fumarate inhibits reaginic antibody-mediated hypersensitivity reactions. In this study, the proliferative responses of peripheral blood mononuclear cells (PBMCs) to ovalbumin (OA) in children with atopic dermatitis (AD), who are sensitive to hen's egg, were significantly higher than those of healthy children. The proliferative responses of PBMCs to OA were dose-dependently inhibited by ketotifen in patients with hen's egg-sensitive AD. Moreover… CONTINUE READING