Suppression of proliferative cholangitis in a rat model by local delivery of paclitaxel.

@article{Park2003SuppressionOP,
  title={Suppression of proliferative cholangitis in a rat model by local delivery of paclitaxel.},
  author={Seon-Mee Park and Jae-Woon Choi and Seung-Taik Kim and Myung-Chan Cho and Ryo Hyen Sung and Lee-Chan Jang and Jin-Woo Park and Sum Ping Lee and Yong-Hyun Park},
  journal={Journal of hepato-biliary-pancreatic surgery},
  year={2003},
  volume={10 2},
  pages={
          176-82
        }
}
BACKGROUND Proliferative cholangitis (PC) leads to biliary stricture, which is the main cause of hepatolithiasis, recurrent cholangitis, and biliary cirrhosis. The aim of this study was to determine whether local delivery of paclitaxel, which inhibits cell proliferation by overstabilization of microtubules, prevents PC in a rat model. METHODS PC was induced by introducing a fine nylon thread into the bile duct in a rat. Paclitaxel (100 microl of 10, 100, and 1000 micromol/l) or solvent… CONTINUE READING