Suppression of pro-inflammatory cytokine release by selective inhibition of inducible nitric oxide synthase in mucosal explants from patients with ulcerative colitis.

@article{Kankuri2003SuppressionOP,
  title={Suppression of pro-inflammatory cytokine release by selective inhibition of inducible nitric oxide synthase in mucosal explants from patients with ulcerative colitis.},
  author={Esko Kankuri and Mari H{\"a}m{\"a}l{\"a}inen and Mika V J Hukkanen and Pertteli Salmenper{\"a} and Eero O. Kivilaakso and Heikki Vapaatalo and Eeva Moilanen},
  journal={Scandinavian journal of gastroenterology},
  year={2003},
  volume={38 2},
  pages={186-92}
}
BACKGROUND In ulcerative colitis (UC), inflammatory damage is associated with increased production of pro-inflammatory cytokines and nitric oxide through the inducible nitric oxide synthase (iNOS) pathway. In an animal model of acute experimental colitis we have previously shown amelioration of inflammation with the highly selective iNOS inhibitor 1400W. The aim of the present study was to investigate the effects of selective iNOS inhibition on the production of pro-inflammatory cytokines by… CONTINUE READING

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