Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis.

@article{Senoo2010SuppressionOP,
  title={Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis.},
  author={Tadashi Senoo and Noboru Hattori and Takuya Tanimoto and Makoto Furonaka and Nobuhisa Ishikawa and Kazunori Fujitaka and Yoshinori Haruta and Hiroshi Murai and Akihito Yokoyama and Nobuoki Kohno},
  journal={Thorax},
  year={2010},
  volume={65 4},
  pages={334-40}
}
BACKGROUND AND AIM There is a growing body of evidence demonstrating that plasminogen activator inhibitor-1 (PAI-1) is involved in the progression of pulmonary fibrosis. In fact, PAI-1 knockout mice are protected from bleomycin-induced pulmonary fibrosis. This study was conducted to determine whether the intrapulmonary administration of small interfering RNA (siRNA) targeting PAI-1 (PAI-1-siRNA) limits the development of bleomycin-induced pulmonary fibrosis. METHODS Lung biopsies from… CONTINUE READING

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