Suppression of p53 potentiates chemosensitivity in nutrient-deprived cholangiocarcinoma cells via inhibition of autophagy

@inproceedings{Hu2017SuppressionOP,
  title={Suppression of p53 potentiates chemosensitivity in nutrient-deprived cholangiocarcinoma cells via inhibition of autophagy},
  author={Fei Hu and Xian-ling Guo and Shanshan Zhang and Qiu-dong Zhao and Rong Li and Qing Rong Xu and Lixin Wei},
  booktitle={Oncology letters},
  year={2017}
}
Tumor protein p53 has been intensively studied as a major tumor suppressor. The activation of p53 is associated with various anti-neoplastic functions, including cell senescence, cell cycle arrest, apoptosis and inhibition of angiogenesis. However, the role of p53 in cancer cell chemosensitivity remains unknown. Cholangiocarcinoma cell lines QBC939 and RBE were grown in full-nutrient and nutrient-deprived conditions. The cell lines were treated with 5-fluorouracil or cisplatin and the rate of… CONTINUE READING
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