Suppression of p38-stress kinase sensitizes quiescent leukemic cells to anti-mitotic drugs by inducing proliferative responses in them.

@article{Vaidya2008SuppressionOP,
  title={Suppression of p38-stress kinase sensitizes quiescent leukemic cells to anti-mitotic drugs by inducing proliferative responses in them.},
  author={Anuradha A Vaidya and Monika B Sharma and Vaijayanti P Kale},
  journal={Cancer biology & therapy},
  year={2008},
  volume={7 8},
  pages={1232-40}
}
Quiescent cells pose a formidable challenge in clinical management of leukemia, since they escape chemo-radiotherapy and become a source of post-therapy relapse. These cells may be refractory to various known growth-promoting signals, making it imperative to identify the biochemical signals necessary to coax them into mitosis. Using serum-starved cell lines as an experimental model of quiescent leukemic cells (QLCs), we demonstrate that a suppression of p38 stress kinase by pharmacological… CONTINUE READING