Suppression of osteoprotegerin expression by prostaglandin E2 is crucially involved in lipopolysaccharide-induced osteoclast formation.

@article{Suda2004SuppressionOO,
  title={Suppression of osteoprotegerin expression by prostaglandin E2 is crucially involved in lipopolysaccharide-induced osteoclast formation.},
  author={Koji Suda and Nobuyuki Udagawa and Nobuaki Sato and Masamichi Takami and Kanami Itoh and J E Woo and Naoyuki Takahashi and Kazuo Nagai},
  journal={Journal of immunology},
  year={2004},
  volume={172 4},
  pages={2504-10}
}
LPS is a potent stimulator of bone resorption in inflammatory diseases. The mechanism by which LPS induces osteoclastogenesis was studied in cocultures of mouse osteoblasts and bone marrow cells. LPS stimulated osteoclast formation and PGE(2) production in cocultures of mouse osteoblasts and bone marrow cells, and the stimulation was completely inhibited by NS398, a cyclooxygenase-2 inhibitor. Osteoblasts, but not bone marrow cells, produced PGE(2) in response to LPS. LPS-induced osteoclast… CONTINUE READING