Suppression of ongoing ocular inflammatory disease by topical administration of plasmid DNA encoding IL-10.

@article{Daheshia1997SuppressionOO,
  title={Suppression of ongoing ocular inflammatory disease by topical administration of plasmid DNA encoding IL-10.},
  author={Massoud Daheshia and Nelly A. Kuklin and Siva Kanangat and Elanchezhiyan Manickan and Barry T Rouse},
  journal={Journal of immunology},
  year={1997},
  volume={159 4},
  pages={1945-52}
}
Ocular infection with herpes simplex virus leads to an inflammatory lesion in the cornea orchestrated by CD4+ Th1 lymphocytes. This immunopathologic disease, called herpetic stromal keratitis, is an important cause of impaired vision. In this study, we set out to determine whether established lesions of herpetic stromal keratitis could be controlled by topically administering naked plasmid DNA encoding cytokines to the corneal surface. A single topical administration of DNA encoding IL-10 was… CONTINUE READING