Suppression of oncogenic viral interferon regulatory factor (vIRF) of Kaposi's sarcoma–associated herpesvirus by ribozyme-mediated cleavage

@article{Zhang2001SuppressionOO,
  title={Suppression of oncogenic viral interferon regulatory factor (vIRF) of Kaposi's sarcoma–associated herpesvirus by ribozyme-mediated cleavage},
  author={Yanjin Zhang and Xin-ping Wang and J Deng and Richard A Salinas and Noboru Oishi and Shou-Jiang Gao},
  journal={Cancer Gene Therapy},
  year={2001},
  volume={8},
  pages={285-293}
}
Kaposi's sarcoma–associated herpesvirus/human herpesvirus 8 (KSHV/HHV8) has been etiologically associated with several malignancies including Kaposi's sarcoma and primary effusion lymphoma. Oncogenic viral interferon regulatory factor (vIRF) encoded by KSHV ORF-K9 is a homologue of cellular interferon regulatory factor (IRF), and has been demonstrated to inhibit type I/II interferon signal transduction and transform NIH3T3 cells through the interactions with IRF-1, IRF-3, and CBP/p300 proteins… CONTINUE READING