Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin

@article{Wang2008SuppressionON,
  title={Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin},
  author={Chuan-en Wang and Hui Zhou and John Russel McGuire and Vincenzo Cerullo and Brendan Lee and Shihua Li and Xiao-Jiang Li},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={181},
  pages={803 - 816}
}
Mutant huntingtin accumulates in the neuronal nuclei and processes, which suggests that its subcellular localization is critical for the pathology of Huntington's disease (HD). However, the contribution of cytoplasmic mutant huntingtin and its aggregates in neuronal processes (neuropil aggregates) has not been rigorously explored. We generated an intracellular antibody (intrabody) whose binding to a unique epitope of human huntingtin is enhanced by polyglutamine expansion. This intrabody… CONTINUE READING

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