Suppression of neuronal excitability by the secretion of the lamprey (Lampetra japonica) provides a mechanism for its evolutionary stability

  title={Suppression of neuronal excitability by the secretion of the lamprey (Lampetra japonica) provides a mechanism for its evolutionary stability},
  author={Shaopeng Chi and Rong Xiao and Qingwei Li and Liwei Zhou and Rongqiao He and Zhi Qi},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  • Shaopeng Chi, R. Xiao, Z. Qi
  • Published 7 February 2009
  • Biology
  • Pflügers Archiv - European Journal of Physiology
Lampreys are one of the most primitive vertebrates still living today. They attach themselves to the body surface of the host fish through their sucker-like mouths and suck blood of the host for days. Recent fossil evidence has indicated that morphology of lampreys in the late Devonian period, over 360 million years ago, already possessed the present day major characteristics, suggesting the evolutionary stability of a highly specialized parasitic feeding habit. Obviously, nociceptive responses… 

Lamprey buccal gland secretory protein-2 (BGSP-2) inhibits human T lymphocyte proliferation

It is found that lamprey BGSP-2 was able to effectively block the proliferation of T cells in vitro by induc- ing G1/S cell cycle arrest, and has the potential of anti-proliferative effect on PHA-activated T lymphocytes.

Anti-angiogenic activities of CRBGP from buccal glands of lampreys (Lampetra japonica).

Proteomic analysis of buccal gland secretion from fasting and feeding lampreys (Lampetra morii)

When lampreys attack host fishes to suck blood and flesh, their buccal glands could secrete enough proteins to suppress blood coagulation, nociception, oxidative stress, immune response, as well as other adverse effects encountered during their parasitic lives.

Sea lampreys elicit strong transcriptomic responses in the lake trout liver during parasitism

A strong transcriptional response in the lake trout to lamprey parasitism that entails genes involved in the regulation of inflammation and cellular damage is indicated.

Identification and Characterization of the Lamprey High-Mobility Group Box 1 Gene

It is revealed that lampreys use HMGB1 to activate their innate immunity for the purpose of pathogen defense and was able to induce the production of tumor necrosis factor-α (TNF-α), a pro-inflammatory mediator, in activated human acute monocytic leukemia cells.

Cloning and expression analysis of a novel high-mobility group box 2 homologue from Lampetra japonica

High-mobility group box 2 (HMGB2) is a nonhistone architectural protein that plays important roles in many biological processes. In this study, we cloned a homologue of the HMGB2 from the

Cysteine-Rich Secretory Proteins (CRISPs) from Venomous Snakes: An Overview of the Functional Diversity in a Large and Underappreciated Superfamily

Snake venom CRISPs may not be lethal or major components of venoms, but given their almost ubiquitous occurrence in venoms and the accelerated evolution of svCRISP genes, these venom proteins are likely to have functions worth investigating.



Novel cysteine-rich secretory protein in the buccal gland secretion of the parasitic lamprey, Lethenteron japonicum.


The secretion of the buccal glands is shown to prevent the clotting of blood even when the secretion is obtained from the glands of non-parasitic lampreys, suggesting that the nonparasites lampreys are neotenous forms living in a restricted environment, but which have not lost the anatomical features possessed by their parasitic relatives.

Biology and Physiology of Feeding in Adult Lampreys

Although landlocked sea lampreys (Petromyzon marinus) attack all but a few of the smallest teleosts in the Great Lakes, the large cold-water species have received the most predation. Information on

A lamprey from the Devonian period of South Africa

A marine/estuarine fossil lamprey from the Famennian (Late Devonian) of South Africa is reported, the identity of which is established easily because many of the key specializations of modern forms are already in place, evidence that agnathans close to modern lampreys had evolved before the end of the Devonian period.

Feeding and breathing in lampreys.

In Mallatt's current models, the earliest vertebrates breathed by branchial contractions and valves; jaws initially evolved for better ventilation and later were used for feeding, and lampreys and their ammocoete larvae are represented.

Palaeontology: Modern look for ancient lamprey

  • P. Janvier
  • Environmental Science, Geography
  • 2006
A recently discovered lampreys fossil dates from the twilight age of their supposed ancestors, and looks surprisingly modern, and is now joined by a well preserved fossil from the Devonian of South Africa, which is the oldest known lampreys.

Action of the saliva of Triatoma infestans (Heteroptera: Reduviidae) on sodium channels.

The data demonstrate that the saliva of T. infestans has an inhibitory effect on Na+ channels, which may decrease the generation and conduction of nerve action potential, thereby decreasing the sensitivity of the region in which the insect probes, in a manner similar to that of local anesthetics.

Mechanoreceptive and nociceptive responses in the central nervous system of goldfish (Carassius auratus) and trout (Oncorhynchus mykiss).

  • R. DunlopP. Laming
  • Biology, Psychology
    The journal of pain : official journal of the American Pain Society
  • 2005

Genomic organization of a voltage-gated Na+ channel in a hydrozoan jellyfish: insights into the evolution of voltage-gated Na+ channel genes.

The genomic organization of the Na+ channel alpha subunit, PpSCN1, from the hydrozoan jellyfish, Polyorchis penicillatus, is described and it is shown that most of the 20 intron sites in this diploblast are conserved in mammalian Na+Channel genes, with some even shared by Ca2+ channels.