Suppression of neurokinin-1 receptor in trigeminal ganglia attenuates central sensitization following inflammation.

@article{Takeda2012SuppressionON,
  title={Suppression of neurokinin-1 receptor in trigeminal ganglia attenuates central sensitization following inflammation.},
  author={Mamoru Takeda and Masayuki Takahashi and Shigeji Matsumoto},
  journal={Journal of the peripheral nervous system : JPNS},
  year={2012},
  volume={17 2},
  pages={169-81}
}
This study examined whether local application of a neurokinin-1 (NK1) receptor antagonist into the trigeminal ganglia (TRGs) modulates hyperexcitability of trigeminal spinal nucleus caudalis (SpVc) wide-dynamic range (WDR) neuron activity innervating both the temporomandibular joint (TMJ) region and facial skin following TMJ inflammation. Extracellular single unit recording combined with multibarrel electrodes was used. TMJ inflammation was induced by the injection of complete Freund's adjuvant… CONTINUE READING

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