Suppression of neurocognitive damage in LP-BM5-infected mice with a targeted deletion of the TNF-alpha gene.

@article{Iida2000SuppressionON,
  title={Suppression of neurocognitive damage in LP-BM5-infected mice with a targeted deletion of the TNF-alpha gene.},
  author={Ryu Iida and Kuniaki Saito and Kiyofumi Yamada and Anthony S. Basile and Kenji Sekikawa and Motohiko Takemura and Hajime Fujii and Hiroshi Wada and Mitsuru Seishima and Toshitaka Nabeshima},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2000},
  volume={14 7},
  pages={1023-31}
}
Brain levels of TNF-alpha increase in many inflammatory conditions, including HIV-1 infection, and may contribute to neurodegenerative processes. The paucity of agents that can selectively and potently block TNF-alpha processing or its receptors has led us to investigate the role of TNF-alpha in chronic neurodegeneration associated with retroviral infection using mice with targeted deletions of the TNF-alpha gene. Infection of wild-type C57BL/6 mice with the LP-BM5 murine leukemia retrovirus… CONTINUE READING
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The influence of a targeted deletion of the IFN g gene on emotional behaviors

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  • Brain Behav. Immun
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