Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C.

@article{Hall1988SuppressionON,
  title={Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C.},
  author={Frederick L. Hall and Paul Fernyhough and Douglas N. Ishii and P. Richard Vulliet},
  journal={The Journal of biological chemistry},
  year={1988},
  volume={263 9},
  pages={4460-6}
}
The formation of vertebrate neural circuitry is regulated in part by neurotrophic agents, such as nerve growth factor (NGF); however, the biochemical mechanisms involved in neurite outgrowth have yet to be completely resolved. Phorbol ester tumor promoters are known to influence the extension of neurites in a variety of neurodevelopmental systems, and protein kinase C, the major phorbol ester receptor, has been implicated in this process. In the present study, sphingosine, a specific… CONTINUE READING