Suppression of natural antitumour defence mechanisms by phorbol esters

  title={Suppression of natural antitumour defence mechanisms by phorbol esters},
  author={Roland Keller},
Chemical carcinogenesis in certain tissues occurs in at least two stages: initiation, producing irreversible tissue alterations, and promotion (by agents, themselves non-carcinogenic), enhancing the outgrowth of transformed cells1,2. Among the various tumour-promoting compounds isolated from croton oil, phorbol-12-myristate-13-acetate (PMA), is the most potent3. Cell culture studies have shown that the phorbol diesters and structurally related substances induce a variety of dramatic changes in… CONTINUE READING
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