• DOI:10.1182/BLOOD-2002-06-1677
Corpus ID: 10863160

Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.

@article{Mizuki2003SuppressionOM,
  title={Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.},
  author={M. Mizuki and Joachim Schwable and C. Steur and C. Choudhary and Shuchi Agrawal and B. Sargin and B. Steffen and I. Matsumura and Y. Kanakura and F. B{\"o}hmer and C. M{\"u}ller-Tidow and W. Berdel and H. Serve},
  journal={Blood},
  year={2003},
  volume={101 8},
  pages={
          3164-73
        }
}

M. Mizuki, Joachim Schwable, +10 authors H. Serve

Published 2003

Biology, Medicine

Blood

The receptor tyrosine kinase Flt3 is expressed and functionally important in early myeloid progenitor cells and in the majority of acute myeloid leukemia (AML) blasts. Internal tandem duplications (ITDs) in the juxtamembrane domain of the receptor occur in 25% of AML cases. Previously, we have shown that these mutations activate the receptor and induce leukemic transformation. In this study, we performed genome-wide parallel expression analyses of 32Dcl3 cells stably transfected with either… CONTINUE READING

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