Suppression of murine endotoxic shock by sPLA2 inhibitor, indoxam, through group IIA sPLA2-independent mechanisms.

@article{Yokota1999SuppressionOM,
  title={Suppression of murine endotoxic shock by sPLA2 inhibitor, indoxam, through group IIA sPLA2-independent mechanisms.},
  author={Yukako Yokota and Kohji Hanasaki and Takashi Ono and Hitoshi Nakazato and Takako Kobayashi and Hitoshi Arita},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1438 2},
  pages={213-22}
}
Endotoxic shock is a systemic inflammatory process, involving a variety of proinflammatory mediators. Two types of secretory phospholipase A2 (sPLA2) have been implicated in this process. Group IB sPLA2 (PLA2-IB) binds to the PLA2 receptor (PLA2R), and PLA2R-deficient mice exhibit resistance to endotoxin-induced lethality with reduced plasma levels of proinflammatory cytokines, such as TNF-alpha. Group IIA sPLA2 (PLA2-IIA) is found in many tissues and cell types, and local and systemic levels… CONTINUE READING

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