Suppression of monocyte 85-kDa phospholipase A2 by antisense and effects on endotoxin-induced prostaglandin biosynthesis.

@article{Roshak1994SuppressionOM,
  title={Suppression of monocyte 85-kDa phospholipase A2 by antisense and effects on endotoxin-induced prostaglandin biosynthesis.},
  author={Amy K. Roshak and Ganesh Sathe and Lisa A. Marshall},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 42},
  pages={25999-6005}
}
Studies were conducted to characterize a human monocyte model where the role of the 85-kDa phospholipase A2 (PLA2) in prostanoid formation could be evaluated. The presence of an immunologically related 85-kDa PLA2 and type II 14-kDa PLA2 was demonstrated in human monocytes and their roles examined in lipopolysaccharide (LPS)-induced monocyte prostaglandin… CONTINUE READING