Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis.

@article{Qi2007SuppressionOM,
  title={Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis.},
  author={Xiaoping Qi and Alfred S Lewin and Liang Sun and William W. Hauswirth and John Guy},
  journal={Investigative ophthalmology & visual science},
  year={2007},
  volume={48 2},
  pages={681-91}
}
PURPOSE Axonal loss is thought to contribute to the persistence of visual loss in optic neuritis and multiple sclerosis (MS). The mechanisms of injury are poorly understood. The authors investigated the contribution of mitochondrial oxidative stress and the effects of modulating mitochondrial antioxidant gene expression in the optic nerves of mice induced with experimental allergic encephalomyelitis (EAE), with a focus on long-term neuroprotection. METHODS Optic nerves from mice with EAE were… CONTINUE READING

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