Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation.

@article{Honor2003SuppressionOM,
  title={Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation.},
  author={St{\'e}phane Honor{\'e} and K Ghanashyam Kamath and Diane Braguer and Leslie Wilson and Claudette Briand and Mary Ann Jordan},
  journal={Molecular cancer therapeutics},
  year={2003},
  volume={2 12},
  pages={1303-11}
}
Discodermolide is a new microtubule-targeted drug in Phase I clinical trials that inhibits tumor growth and induces G(2)-M cell cycle arrest. It is effective against paclitaxel-resistant cell lines and acts synergistically in combination with paclitaxel. Suppression of microtubule dynamics by microtubule-targeted drugs has been hypothesized to be… CONTINUE READING