Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity.

@article{Gmez2014SuppressionOM,
  title={Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity.},
  author={G. J. Garc{\'i}a G{\'o}mez and Stefano Volinia and Carlo M. Croce and Ciro Zanca and Ming Li and Ryan J. Emnett and David H Gutmann and C. V. Weiss Brennan and Frank B Furnari and Webster K Cavenee},
  journal={Cancer research},
  year={2014},
  volume={74 5},
  pages={1429-39}
}
The EGF receptor (EGFR) is amplified and mutated in glioblastoma, in which its common mutation (ΔEGFR, also called EGFRvIII) has a variety of activities that promote growth and inhibit death, thereby conferring a strong tumor-enhancing effect. This range of activities suggested to us that ΔEGFR might exert its influence through pleiotropic effectors, and we hypothesized that microRNAs might serve such a function. Here, we report that ΔEGFR specifically suppresses one such microRNA, namely miR-9… CONTINUE READING

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