Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats

@article{Liu2013SuppressionOM,
  title={Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats},
  author={Yao-Wu Liu and Xi Zhu and Qian-qian Yang and Qian Lu and Jian-yun Wang and Hui-Pu Li and Ya-qin Wei and Jia-le Yin and Xiaoxing Yin},
  journal={Psychopharmacology},
  year={2013},
  volume={228},
  pages={585-594}
}
Evidences indicate that methylglyoxal, a highly reactive metabolite of hyperglycemia, can enhance protein glycation, oxidative stress, or inflammation. Mangiferin, a polyphenol compound of C-glucoside, has many beneficial biological activities, including anti-inflammation, anti-oxidation, neuroprotection, cognitive enhancement, etc. Whether mangiferin alleviates diabetes-associated cognitive impairment is still unclear. The present study was designed to investigate the effects of mangiferin on… CONTINUE READING
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