Suppression of mature dendritic cell function by regulatory T cells in vivo is abrogated by CD40 licensing.

@article{Hnig2008SuppressionOM,
  title={Suppression of mature dendritic cell function by regulatory T cells in vivo is abrogated by CD40 licensing.},
  author={Jens H{\"a}nig and Manfred B Lutz},
  journal={Journal of immunology},
  year={2008},
  volume={180 3},
  pages={1405-13}
}
The priming of CD4+ effector T cells (T(eff)) in vivo is induced by mature dendritic cells (DC) and controlled by CD4+CD25+Foxp3+ regulatory T cells (T(reg)). It remains unclear,however, how T(eff) priming vs T(reg) suppression are regulated during Ag presentation by DC in secondary lymphoid organs at the simultaneous presence of T(eff) and T(reg). In this study, we used an peptide-specific DO11.10 TCR-transgenic adoptive transfer model to follow the T(eff) priming kinetics and the mechanisms… CONTINUE READING

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