Suppression of matrix protein synthesis by herpes simplex virus in bovine smooth muscle cells.

@article{Lashgari1987SuppressionOM,
  title={Suppression of matrix protein synthesis by herpes simplex virus in bovine smooth muscle cells.},
  author={M S Lashgari and Harvey M. Friedman and Nicholas A. Kefalides},
  journal={Biochemical and biophysical research communications},
  year={1987},
  volume={143 1},
  pages={145-51}
}
We investigated the effect of herpes simplex virus type 1 infection on the synthesis of extracellular matrix proteins by bovine smooth muscle cells. The cells supported viral replication, which reached maximum at 24 hrs post-infection. Uninfected and infected (multiplicity of infection of 5 or 20) cultures of smooth muscle cells were labeled with [14C]proline at five hrs post-infection. Incorporation of radioactivity into non-dializable protein was determined following electrophoresis of the… CONTINUE READING