Suppression of matrix metalloproteinase-9 by prostaglandin E(2) in peritoneal macrophage is associated with severity of endometriosis.

@article{Wu2005SuppressionOM,
  title={Suppression of matrix metalloproteinase-9 by prostaglandin E(2) in peritoneal macrophage is associated with severity of endometriosis.},
  author={Meng-Hsing Wu and Yutaka Shoji and Meng-Chi Wu and Pei-Chin Chuang and Chen-Chung Lin and M Huang and Shaw-Jenq Tsai},
  journal={The American journal of pathology},
  year={2005},
  volume={167 4},
  pages={1061-9}
}
Decreased phagocytotic ability of macrophages has been reported to be associated with the severity of endometriosis, although the underlying mechanism remains uncharacterized. Expression and secretion of matrix metalloproteinase (MMP)-9 by macrophages is a means to degrade the extracellular matrix of cells that are designated for phagocytosis. Here, we describe the regulation of MMP-9 expression and activity in peritoneal macrophages of women with endometriosis. Results demonstrated that… CONTINUE READING