Suppression of mammary gland carcinogenesis by post-initiation treatment of rats with tamoxifen or indole-3-carbinol or their combination

@article{MalejkaGiganti2007SuppressionOM,
  title={Suppression of mammary gland carcinogenesis by post-initiation treatment of rats with tamoxifen or indole-3-carbinol or their combination},
  author={D. Malejka-Giganti and Daniel R. Parkin and K. Bennett and Yongjian Lu and R. W. Decker and G. Niehans and R. Bliss},
  journal={European Journal of Cancer Prevention},
  year={2007},
  volume={16},
  pages={130-141}
}
  • D. Malejka-Giganti, Daniel R. Parkin, +4 authors R. Bliss
  • Published 2007
  • Medicine
  • European Journal of Cancer Prevention
  • This study examined whether suppression of mammary gland carcinogenesis elicited by low doses of tamoxifen (TAM) can be enhanced by concomitant treatment of rats with indole-3-carbinol (I3C), a component of cruciferous vegetables and a dietary supplement used for its putative antiestrogenicity. Two weeks after one oral dose of 7,12-dimethylbenz[a]anthracene (DMBA) at 65 mg/kg body weight, female Sprague–Dawley rats started treatment with TAM (10 μg/rat) by subcutaneous injection, I3C (250 mg/kg… CONTINUE READING
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