Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats.

@article{Imamura2005SuppressionOM,
  title={Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats.},
  author={Michio Imamura and Tadashi Ogawa and Yasuyuki Sasaguri and Kazuaki Chayama and Hikaru Ueno},
  journal={Gastroenterology},
  year={2005},
  volume={128 1},
  pages={
          138-46
        }
}
BACKGROUND & AIMS Monocytes/macrophages infiltrate into injured livers. We tried to clarify their roles in inflammation and subsequent fibrogenesis by inhibiting their infiltration with a mutated form (7ND; 7 amino acids at the N-terminal were deleted) of monocyte chemoattractant protein 1, which may function as a dominant-negative mutant. METHODS Rats were injected via the tail vein with an adenovirus expressing either human 7ND (Ad7ND), a truncated type II transforming growth factor beta… CONTINUE READING
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