Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity.

@article{Li2013SuppressionOL,
  title={Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity.},
  author={Min Li and Bilon Khambu and Hao Zhang and Jeong-han Kang and Xiaoyun Chen and Daohong Chen and Laura L. Vollmer and Peiqing Liu and Andreas Vogt and Xiao-ming Yin},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 50},
  pages={35769-80}
}
Autophagy can be activated via MTORC1 down-regulation by amino acid deprivation and by certain chemicals such as rapamycin, torin, and niclosamide. Lysosome is the degrading machine for autophagy but has also been linked to MTORC1 activation through the Rag/RRAG GTPase pathway. This association raises the question of whether lysosome can be involved in the initiation of autophagy. Toward this end, we found that niclosamide, an MTORC1 inhibitor, was able to inhibit lysosome degradation and… CONTINUE READING

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