Suppression of lymphokine-activated killer induction by neutrophils.

@article{Shau1988SuppressionOL,
  title={Suppression of lymphokine-activated killer induction by neutrophils.},
  author={Hungyi Shau and Andrew Kim},
  journal={Journal of immunology},
  year={1988},
  volume={141 12},
  pages={4395-402}
}
Peripheral blood polymorphonuclear neutrophils (PMN) suppressed the induction of PBL lymphokine-activated killer (LAK) function by rIL-2 in vitro. The suppression depended on the concentration of PMN in the IL-2 culture, and required intact PMN. However, PMN did not require treatment with immunoregulators such as IL-2, LPS, or TNF to express the suppressive activity, and no direct contact with PBL was needed for the suppression. Addition of anti-TNF antibodies had no effect on the suppression… CONTINUE READING

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