Suppression of lymphocyte proliferative responses by sera from patients with American visceral leishmaniasis.

@article{Barral1986SuppressionOL,
  title={Suppression of lymphocyte proliferative responses by sera from patients with American visceral leishmaniasis.},
  author={Aldina Barral and Edgar Marcelino de Carvalho and Roberto Badar{\'o} and Manoel Barral-Netto},
  journal={The American journal of tropical medicine and hygiene},
  year={1986},
  volume={35 4},
  pages={
          735-42
        }
}
We examined the effect of sera from 11 patients with American visceral leishmaniasis on mitogen-driven lymphocyte proliferative capacity. All sera inhibited lymphocyte proliferation of patients' peripheral blood mononuclear cells (PBMC) when stimulated by either phytohemagglutinin, Concanavalin A or pokeweed mitogen. Serum was also strongly inhibitory for Concanavalin A-pulsed normal volunteers' PMBC. The effect of the serum was not due to cytotoxicity, inadequate nutritional support or altered… CONTINUE READING

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Immunoactivation and immunopathogeny during active visceral leishmaniasis.

  • Revista do Instituto de Medicina Tropical de Sao Paulo
  • 2009
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