Suppression of lymphocyte mitogenesis by tamoxifen.

  title={Suppression of lymphocyte mitogenesis by tamoxifen.},
  author={E Baral and Sukyee Kwok and Istvan Berczi},
  volume={18 1},
Tamoxifen (at 0.1-1 microM concentrations) inhibited significantly the response of rat spleen cells to phytohemagglutinin, concanavalin A, pokeweed mitogen and lipid A in a dose-dependent manner. To achieve this inhibition, it was sufficient to expose the lymphocytes for 4 h to tamoxifen prior to mitogenic stimulation. Estradiol did not have a consistent effect on lymphocyte mitogenesis under the same conditions and did not modify the suppressive effect of tamoxifen, even when the lymphocytes… CONTINUE READING