Suppression of lung cancer cell invasion by LKB1 is due to the downregulation of tissue factor and vascular endothelial growth factor, partly dependent on SP1.

@article{Liang2014SuppressionOL,
  title={Suppression of lung cancer cell invasion by LKB1 is due to the downregulation of tissue factor and vascular endothelial growth factor, partly dependent on SP1.},
  author={Xuan Liang and Zhao-lun Li and Li-li Jiang and Qian-qian Guo and Meng-jie Liu and Kejun Nan},
  journal={International journal of oncology},
  year={2014},
  volume={44 6},
  pages={1989-97}
}
LKB1 encodes a serine/threonine kinase generally inactivated in many human cancers, which mediates cancer cell proliferation, migration and differentiation. Recent studies indicated that LKB1 exhibits potent anti-metastatic activity. However, the underlying molecular mechanisms of this activity remain unclear. In this study, we re‑introduced LKB1 into A549 lung cancer cells that lack the LKB1 gene to investigate how LKB1 affects tumor invasiveness and metastasis. We demonstrated that… CONTINUE READING

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