Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways.

@article{Mabley2004SuppressionOI,
  title={Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways.},
  author={J. Mabley and P. Pacher and P. Bai and Rebecca Wallace and S. Goonesekera and L. Vir{\'a}g and G. Southan and C. Szab{\'o}},
  journal={Mutation research},
  year={2004},
  volume={548 1-2},
  pages={
          107-16
        }
}
Min mice have a germ-line nonsense mutation at codon 850 of the adenomatous polyposis coli (Apc) gene. These mice spontaneously develop multiple polyps in the small and large intestine at the age of 10-12 weeks. The aim of this study was to assess the role of reactive nitrogen species and poly(ADP-ribose) synthetase in tumorogenesis. Oxidative stress was found to be increased in the mucosa of the small intestine of Apc(min/+) mice with a concomitant increase in intestinal polyposis over control… Expand
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Results suggest that iNOS-selective inhibitors could be used as a potential chemopreventive agent for colorectal cancers. Expand
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