Suppression of interleukin 2 production in an animal model of thermal injury is related to prostaglandin synthesis.

@article{Wood1987SuppressionOI,
  title={Suppression of interleukin 2 production in an animal model of thermal injury is related to prostaglandin synthesis.},
  author={Jennifer J Wood and John T. Grbic and Mary L. Rodrick and Andrea L. Jordan and John A. Mannick},
  journal={Archives of surgery},
  year={1987},
  volume={122 2},
  pages={179-84}
}
We performed studies using an animal model of thermal injury to confirm the observed decrease in interleukin 2 (IL-2) production in burned patients and to explore the underlying mechanisms. Ten mice subjected to a 25% scald were compared with ten anesthetized littermates (controls) and six untreated mice (normal mice) 1, 3, 5, 7, 10, 14, and 21 days after burn. Production of IL-2 by splenocytes was stimulated by concanavalin A alone, or in the presence of the cyclooxygenase inhibitor… CONTINUE READING

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